DAY 1: Wednesday June 15th 2022

Time

Event/Title

Speaker

8:15 - 9:15 AM

Live Online Poster Presentations
and Discussion

Facilitated by Senior Chairs

9:15 - 9:45 AM

COFFEE BREAK

9:45 - 9:50 AM

Welcome to Conference

Alan Thomas (Chair)

9:50 - 10:00 AM

Welcome to Newcastle

Professor David Burn (Pro-Vice Chancellor, Faculty of Medicine)

10:00 - 11:30 AM

Symposium 1: Fluid Biomarkers
Session Co-Chairs:
Omar El-Agnaf (Doha, Qatar)
Henrik Zetterberg (Gothenburg, Sweden)
Speakers:
Alison Green (Edinburgh, UK): Seeding assays for alpha-synuclein
Maria Camila Gonzalez (Stavanger, Norway): Blood biomarkers and disease progression within the E-DLB cohort
Nick Ashton (Gothenburg, Sweden): Plasma p-tau and relation to Neuropathology
Omar El-Agnaf (Doha, Qatar): alpha-synuclein oligomers in LBD
Elijah Mak (Cambridge, UK): Structural imaging correlates of plasma biomarkers in dementia with Lewy bodies
Paul Donaghy (Newcastle, UK): Correlation between plasma biomarkers and amyloid PET in dementia with Lewy bodies

11:30 - 11:45 AM

SHORT BREAK

11:45 - 1:15 PM

Symposium 2: Prodromal DLB
Session Co-Chairs:
Laura Bonanni (Chieti, Italy)
Paul Donaghy (Newcastle, UK)
Speakers:
Laura Bonanni (Chieti, Italy): Delirium and EEG
Alan Thomas (Newcastle, UK): Imaging biomarkers in MCI-LB
Alex Iranzo (Barcelona, Spain): RBD
Evelien Lemstra (Amsterdam, Netherlands): Clinical progression and Fluid biomarkers
Brad Boeve (Rochester, USA): Baseline and Longitudinal Ioflupane SPECT Findings in MCI-LB, MCI-LB to DLB Phenoconverters and DLB
Kathryn Wyman-Chick (Minnesota, USA): Clinical features in prodromal disease: Comparing dementia with Lewy bodies with Alzheimer’s disease

1:15 - 2:15 PM

LUNCH

2.15 - 3.45 PM

Symposium 3: Genetics and Epigenetics
Session Co-Chairs:
Chris Morris (Newcastle, UK)
Katie Lunnon (Exeter, UK)
Speakers:
Katie Lunnon (Exeter, UK): Epigenetics
Leonidas Chouliaras (Cambridge, UK): Neuron-specific epigenetic profiling in LBD
Sonja Scholz (Bethesda, USA): Whole Genome Sequencing in Dementia with Lewy Bodies
Mina Ryten (London, UK): Transcriptional Profiling in Lewy Body Disease
Anna McKeever (Cambridge, UK): Including Alzheimer’s Disease polygenic risk score improves the classification of Lewy Body and Alzheimer’s Disease Dementia available from plasma biomarkers
Aaron Wagen (London, UK): Identifying local genetic correlations among neurodegenerative and neuropsychiatric diseases

3:45 - 4:15 PM

COFFEE BREAK

4.15 - 5.30 PM

Joint Plenary with Lewy Body Society
Chairs: Alan Thomas (Newcastle, UK) and Jacqui Cannon (Lewy Body Society, UK)

4:15 - 4:45 PM

DLB: Past, Present and Future

John O’Brien (Cambridge, UK)

4:45 - 5:15 PM

Lewy body dementia:  the invisible monster

Susan Williams (San Francisco, USA)

5:15 - 5:30 PM

Launch of International Coalition of Lewy Body Charities

Lewy Body Society

6:00pm - 8:00pm

Drinks Reception at Baltic Centre for Contemporary Art

DAY 2: Thursday June 16th 2022

Time

Event/Title

Speaker

8.30 - 9:30 AM

Plenary 2
Chairs: Ian McKeith (Newcastle, UK) and Brad Boeve (Rochester, USA)

8:30 - 9:00 AM

Clinical Synucleinopathies

Ron Postuma (McGill, Canada)

9:00 - 9:30 AM

Genetics of PD vs DLB

Andy Singleton (NIH, USA)

9:30 - 9:45 AM

SHORT BREAK

9:45 - 11.15 AM

Symposium 4: Clinical Features
Session Co-Chairs:
Simon Lewis (Sydney, Australia)
Rimona Weil (London, UK)
Speakers:
Manabu Ikeda (Osaka, Japan): A Japanese cross-sectional questionnaire-based study on treatment needs of patients with dementia with Lewy bodies and their caregivers and physicians
Elie Matar (Sydney, Australia): What do symptom clusters tell us about DLB?
Angeliki Zarkali (London, UK): neuropsychiatric features of DLB (Psychosis and depression)
Hiroshige Fujishiro (Nagoya, Japan): Psychiatric Onset of Prodromal DLB
Philip Tipton (Florida, USA): Clinical Trial Feasibility in Symptomatically Treated Dementia with Lewy bodies
Aniek van Gils (Amsterdam, Netherlands):Optimizing cCOG, a web-based tool, to detect dementia with Lewy Bodies

11:15 - 11:45 AM

COFFEE BREAK

11.45 - 1.15PM

Symposium 5: Imaging and EEG
Session Co-Chairs:
Kejal Kantarci (Rochester, USA)
Zuzana Walker (London, UK)
Speakers:
Kejal Kantarci (Rochester, USA): Imaging in Prodromal DLB
Julia Schumacher (Rostock, Germany): EEG in DLB
Dani Ferriera-Padilla (Stockholm, Sweden): MRI in DLB
John Paul Taylor (Newcastle, UK): Cholinergic imaging in Lewy body disease
Patricia Diaz Galvin (Florida, USA): In the LBD continuum, increase in β-amyloid occurs along with cognitive impairment
Anna Inguanzo (Solna, Sweden): MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies

1:15 - 2:15 PM

LUNCH

2.15 - 3.45 PM

Symposium 6: Therapeutics
Session Co-Chairs:
Dan Weintraub (Pennsylvania, USA)
Clive Ballard (Exeter, UK)
Speakers:
Clive Ballard (Exeter, UK): Review of Repurposing Agents
Dag Aarsland (London, UK): Current Trials in DLB
Ira Leroi (Dublin, Ireland): Stimulation and other non-drug therapies for LBD
Stephen Gomperts (Harvard, USA): Cognitive, motor and function effects of neflamapimod
Joseph Kane (Belfast, Northern Ireland): Developing a Core Outcome Set (COS) for clinical trials in dementia with Lewy bodies
Daniel Weintraub (Pennsylvania, USA): Impact of the dopamine system on long-term cognitive impairment in Parkinson Disease: The PPMI Study

3:45 - 4:15 PM

COFFEE BREAK

4.15 - 5.15 PM

Live Online Poster Presentations and Discussion
Facilitated by Senior Chairs

8:00pm - 10:00pm

Dinner at Hilton Hotel
Guest Speaker: Professor Sir John Burn

DAY 3: Friday June 17th 2022

Time

Event/Title

Speaker

8.30 - 9:30 AM

Plenary 3
Chairs: John-Paul Taylor (Newcastle, UK) and Jon Toledo (Florida, USA)

8:30 - 9:00 AM

Neuropathology

Glenda Halliday (Sydney, Australia)

9:00 - 9:30 AM

Back to the future: alpha-synuclein aggregation and beyond

Tiago Outeiro (Gottingen, Germany)

9:30 - 9:45 AM

SHORT BREAK

9:45 - 10.15 AM

Rising Star Presentations: 9:45 - 10:15 AM
Chairs: Jim Leverenz (Cleveland, USA) and Rosie Watson (Melbourne, Australia)

9:45 - 10:00 AM

Rising Star (Preclinical)

To be awarded

10:00 - 10:15 AM

Rising Star (Clinical)

To be awarded

10:15 - 10:45 AM

COFFEE BREAK

10.45 - 12.15PM

Symposium 7: Mechanisms of disease/synuclein spread
Session Co-Chairs:
Tiago Outerio (Gottingen, Germany)
Tim Bartels (London, UK)
Speakers:
Tim Bartels (London, UK): Brain region specific vulnerability to synuclein spread
Wilma van de Berg (Amsterdam, Netherlands): Tales from the human brain: unravelling cellular mechanisms underlying Lewy body formation with multiscale imaging
Han Seok Ko (Baltimore, USA): New rodent model of Parkinson’s disease representing gut-brain alpha-synuclein transmission
Rohan Bhome (London, UK): Thalamic white matter macrostructure and subnuclei volumes in Parkinson’s disease depression
David Koss (Newcastle, UK): Nuclear aSyn pathology and genomic DNA damage: cause or consequence of Lewy body formation?
Marzena Kurzawa-Akanbi (Newcastle, UK): Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders

12:15 – 1:00 PM

LUNCH

1.00 - 2.30 PM

Symposium 8: Neuropathology and Brain Banking
Session Co-Chairs:
Johannes Attems (Newcastle, UK)
Glenda Halliday (Sydney, Australia)
Speakers:
Dennis Dickson (Florida, USA): Lewy body disorders in the Mayo Clinic Jacksonville brain bank
Johannes Attems (Newcastle, UK): Neuropathological consensus criteria for Lewy pathology
Amanda Woerman (Massachusetts, USA): Alpha-synuclein – an update on prion like spread and the interaction with other pathologies
Zane Jaunmuktane (London, UK): Lewy body pathology in the aged population
David Coughlin (California, USA): Variable brain and CSF seeding activity across a spectrum of Lewy related pathology using alpha-synuclein seed amplification assay
Lauren Walker (Newcastle, UK): Investigating the prevalence and severity of cerebral amyloid angiopathy in Lewy body disease

2.30 - 3.15 PM

Debate: It is now time for a trial of an amyloid lowering agent in DLB
Session Co-Chairs: David Burn (Newcastle, UK) and Dag Aarsland (London, UK)

Supporting the Motion: Jim Galvin (Florida, USA)
Opposing the Motion: John Duda (Pennsylvania, USA)

3:15PM

DEPART